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GLP- 1 Receptor Agonists in Development Orforglipron is an oral, non-peptide, small molecule glucagon-like peptide- 1 receptor agonist [104]

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Mulla CM, Goldfine AB, Dreyfuss JM, et al

[34] showed that treatment with the GLP-1 RAs exenatide and liraglutide reduced both systolic and diastolic BP by 1 to 5 mm Hg in patients with T2D, compared with some other anti-diabetic drugs, including insulin, glimepiride, and placebo

These findings all indicate that ferroptosis promotes the development of DCM through abnormal iron metabolism, lipid peroxidation, ROS production, and enhanced cardiomyocyte inflammation (Figure 1)