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Copper itself is a comparatively weak skin sensitizer a 2014 review (PMID 25098945) reported positive copper patch-test reactions in roughly 3.8% of tested subjects so contact allergy is possible but uncommon

(2019) 51:e13263

The gel significantly improved skin permeation, achieving a permeability rate of 61.12 1.89% in ex-vivo studies after 24 h substantially higher than the 8.56 2.5% permeability of commercial clobetasol cream

Trivia The global skin-lightening industry was worth USD 9.7 billion in 2023 and is expected to reach USD 16 billion by 2033

doi: 10.1016/j.jpeds.2016.10.070 20 MastrandreaLDWittenLCarlsson PetriKCHalePMHedmanHKRiesenbergRA

Who can and cannot try IV therapy