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Nat Cell Biol 3 : 114120

Read the evidence A 2017 meta-analysis (N = 1,211) found that in patients with hyperuricaemia and CKD, urate-lowering treatment slowed renal function decline, limited proteinuria and reduced the relative risk of cardiovascular events or renal failure by over 50% 12 A 2020 meta-analysis (N = 6,458) found that urate-lowering treatment did not significantly reduce the risk of major adverse cardiovascular events, kidney failure or all-cause mortality

Available from, as of February 16, 2012: The pharmacologic effects of edetate calcium disodium are due to the formation of chelates with divalent and trivalent metals

L-carnitine is sold as a food supplement for the general adult population

Vitamin B-12 is the largest and most structurally complicated vitamin

It also helps regulate nitric oxide levels, which improves circulation and reduces oxidative stresstwo key components in healing joint injuries