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Furthermore, studies of IGF-2 gene in transitional cell carcinoma of the bladder and MGMT gene in gastric cancer showed that patients with CT or TT MTHFR genotypes had reduced methylation of IGF-2 or MGMT compared those with CC genotype 36,37

In addition, studies suggest roles in angiogenesis, peripheral nerve outgrowth, antioxidant defense, and modulation of inflammatory activity, including in models of chronic pulmonary injury[2]