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The most common adverse effects are gastrointestinal and include nausea, vomiting, diarrhea, constipation, and abdominal pain

This effect is likely mediated by NHE3 inhibition in the proximal renal tubule

Yes, they can often be combined with DMARDs, biologics, and other diabetes drugsalways under close provider supervision. Are GLP-1 medications effective in conditions like rheumatoid arthritis, psoriatic arthritis, lupus, and osteoarthritis

However, side effects such as constipation and slowed digestion may increase flare risk in susceptible individuals

Ectopic tissue releases cytokines, drives oxidative stress, and amplifies pelvic immune activation

The comorbidities associated with it decrease their quality and life expectancy