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Results at 72 weeks showed average weight loss of 15.0% with 5 mg, 19.5% with 10 mg, and 20.9% with 15 mg

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In this trial, MASH resolution without worsening of fibrosis was achieved in 4462% of participants receiving tirzepatide, compared with 10% in the placebo group, and fibrosis improvement of at least one stage without worsening of MASH occurred in up to 55% of tirzepatide-treated individuals versus only 30% with placebo [81]

Adequate calcium and vitamin D, resistance training, and avoiding very rapid weight loss are the practical steps