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Thats not opinion

it means the dose-response, long-term safety, and population-level risk profile of Melanotan II in humans are fundamentally unknown

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and caveolin-1 (CAV1), a scaffold protein of caveolar membranes involved in signal transduction and in the uptake of lipophilic compounds, which directly interacts with NRF2, probably competing with KEAP1 for binding to NRF2, and subsequently suppresses its transcriptional activity [231]

This substantial body of research examined the peptide across numerous systems: gastrointestinal healing, musculoskeletal repair, cardiovascular function, neurological protection, and immunomodulation