The Phase 2 trial results published in 2023 were, by any reasonable measure, extraordinary
Cancer Med 9(10):34893499 Majewska E, Mrquez J, Albrecht J, Szeliga M (2019) Transfection with GLS2 glutaminase (GAB) sensitizes human glioblastoma cell lines to oxidative stress by a common mechanism involving suppression of the PI3K/AKT pathway
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Its oral bioavailability is achieved through the incorporation of the absorption enhancer SNAC (N-[8-(2-hydroxybenzoyl)amino]octanoic acid), which works through two mechanisms: (1) temporarily raising the local pH in the stomach to reduce gastric protease activity
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Huang YL, Moon J, Segal JB