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When nanoparticle-hydrogel used alone or in combination safety issues must be properly investigated

Macrophage depletion can reduce inflammatory cytokines and trigger adiponectin secretion from both SAT and VAT adipocytes, leading to the induction of preadipocyte differentiation in SAT, but not VAT

As this pathway is absent in humans and in human commensal bacteria MTAN is a promising candidate as a target for new drugs

PMID 20814407

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