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In one of the early reports cited by Donnino (69), severe manifestations of gastrointestinal beriberi are also preceded in time by much milder symptoms
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This setup lets you strip away all the other biological noise and focus only on how the pituitary cells respond
All three are actively transported into proximal tubular cells via organic anion transporters (OAT1/3), where they trigger oxidative stress through NADPH oxidase activation and reactive oxygen species (ROS) generation (115, 124)
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