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Many people experience weight loss with Rybelsus due to reduced appetite and slower stomach emptying, although it is not classified as a weight-loss medicine

De Francesco was supported by a fellowship from the Associazione Italiana per la Ricerca sul Cancro (AIRC) co-funded by the European Union

When administered subcutaneously, it binds to GHRH receptors on somatotroph cells in the anterior pituitary, triggering endogenous growth hormone secretion in a pulsatile pattern that mimics natural nocturnal GH release