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When the mast cells degranulate, they release many mediators including histamine, which as discussed above, is believed to cause flushing through its vasodilatory effect on vascular smooth muscle

Mast cell activation is a very important component of treatment often

However, "unlike most other vitamins, B12 is stored in substantial amounts, mainly in the liver, until it is needed by the body," according to Merck Manuals Consumer Version

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Metallothionein Protects the Heart Against Myocardial Infarction via the mTORC2/FoxO3a/Bim Pathway