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2) Abnormally elevated CD163+ macrophages drive excessive complex phagocytosis, leading to macrophage iron overload, LIP expansion, oxidative stress, and ferroptosis

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The controlled environments of clinical trials and the limited participant groups do not fully reflect the variety of metabolic, genetic, and behavioral factors present in real life, which explains the differences between study results and real-world outcomes

3020 Departments of Labor, Health and Human Services, and Education, and Related Agencies Appropriations Act, 2016 Archived 2023-07-05 at the Wayback Machine114th Congress