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This interpretation was further supported by our functional assays, which demonstrated significantly reduced production of IL-5, IL-6, IL-9, IL-10, and IL-13 by melatonin-treated ILC2s

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Therapeutic strategies targeting this cycle -such as Nrf2 activators (sulforaphane), mitochondrial antioxidants (MitoQ), and AGE inhibitors (aminoguanidine)- highlight the dual role of OS as interventions early in DM, which can improve -cell function, while later-stage treatments primarily mitigate complications

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Comment: Commenters were generally supportive of CMS' proposal of the RUC-recommended work RVUs and direct PE inputs for CPT codes 62330 and 62331