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P =0.18), GLP-1 RA were associated with a significant reduction in the incidence of MACE compared with placebo and pioglitazone, with a non-significant trend towards reduction in DPP-4 inhibitor-controlled studies [100]

The peak heart rate effect is temporary, not permanent

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( 10.2337/dc12-2713) [DOI] [PMC free article] [PubMed] [Google Scholar] 10.Waser B, Blank A, Karamitopoulou E, et al