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Exposure to excessive ROS, including free radical superoxide O 2 - , hydrogen peroxide, and hydroxyl radicals, favors oxidative stress, alters mitochondrial Ca 2+ homeostasis, triggers membrane lipid peroxidation and potentially induces nuclear and mtDNA damage [15] .Sustained elevations in intracellular Ca 2+ concentrations ultimately cause neuronal degeneration and cell death by initiating apoptosis [16]

Eur J Heart Fail 22(7):10971107 Jenkins C, Bricknell K, Hanekom L, Marwick TH (2004) Reproducibility and accuracy of echocardiographic measurements of left ventricular parameters using real-time three-dimensional echocardiography

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Zimmerman AW, Jyonouchi H, Comi AM, Connors SL, Milstien S, Varsou A, Heyes MP: Cerebrospinal fluid and serum markers of inflammation in autism

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Testing occurs randomly throughout the season and during the playoffs