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In the non-T2D cohort, total costs were 7 595 634 compared with 6 926 474 for the comparator, with incremental gains of 0.126 QALYs and 0.044 life-years, resulting in an ICER of 5 300 580/QALY

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Pycnogenol is an extract of marine pine bark that includes procyanidins and phenolic acids (Packer 1999)