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Activation of 3-AR via Gs cAMP PKA phosphorylation of hormone-sensitive lipase (HSL) leads to: Splitting of triglycerides into free fatty acids + glycerol Release of fatty acids from adipose tissue into the blood Increased oxidation of fatty acids in mitochondria (muscle, liver) Heffernan et al

Archived from the original on October 16, 2012

Poor sleep quality directly impairs fat metabolism, elevates hunger hormones like ghrelin, and can significantly diminish semaglutides effectiveness by driving appetite signals that compete with the medications benefits

doi:10.1056/NEJMoa2032183 Novo Nordisk Ltd

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