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Real-world results may differ though the consistency of incretin-based therapy data across trials and post-marketing settings is encouraging

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4) Underexplored therapeutic strategies and resistance mechanisms: While combination therapies [e.g., everolimus + erastin/RSL3 (260) and URB597 + RSL3 (264)] show promise, rational combination design remains limited by incomplete mechanistic understanding

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GLP-1 was identified as a key incretin hormone in the 1980 s (Lund et al