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Energy drinks also induced various histological alterations, including vacuolation and lipid infiltration of hepatocytes, developing degenerated glomeruli and dilated interstitial spaces in the renal cortex, pyknosis and chromatolysis of cerebral and medullary neurons, and degenerated and abnormal Purkinje cells in the cerebellum

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In addition, there is evidence that patients with ME/CFS have associations between elevated fatigue and specific SNPs in TNF-, IL1b, IL4, and IL6 genes (90)

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