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We don't need to dose people into complete loss of appetite

& Banik, B

Ye, Yi, et al

Cardiac Physiology and Cardiovascular Research Cardiac muscles high energy demands and reliance on fatty acid oxidation make L-Carnitine particularly relevant for cardiovascular research: Cardiac Metabolism Studies: Investigation of myocardial energy substrate utilization, metabolic remodeling in heart failure, and adaptive responses to hemodynamic stress

McGowan says this is likely due to genetic and physiological mechanisms driving excess weight, adding that when stopping these medications, people experience a rapid return of their hunger

Once glycogen levels drop, the brain triggers hunger signals to refill those stores