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Conversely, the demand for folate is increased when dietary supply for choline is limited (31)

Introduction General anesthesia (GA) is a common clinical intervention, with nearly 230 million surgical procedures taking place under GA across the world every year ( Although the exact mechanisms by which GA agents work are yet to be fully elucidated, they are widely considered to suppress neuronal firing ( Beyond altering neuronal transcription, neuronal activity also has consequences on gene expression in nearby non-neuronal cells

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