The Lancet 1 The information provided here is for educational purposes only and should not be interpreted as medical advice
Tirzepatide-Specific Safety Considerations GI symptoms are generally mild to moderate Risk of hypoglycemia when used with insulin or sulfonylureas Rare risk of pancreatitis (class effect) Possible thyroid C-cell effects (class warning) Heart rate increases have been documented, but are generally modest Retatrutide-Specific Safety Considerations Higher overall rate of side effects compared to tirzepatide in Phase 2 data More pronounced heart rate increase this is a dose-dependent effect directly related to glucagon receptor activation (glucagon is known to increase heart rate in pharmacological doses) At 12 mg doses, some participants experienced increases in heart rate of 46 bpm above baseline
George Georgiou holds the Dula D
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Thankfully, there are so many different options for diabetes medications. With both drugs, the most common side effects tend to subside after days, weeks, or months, as the body becomes accustomed to the new medication or a higher dosage
