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In the randomized placebo-controlled HOME trial of 390 adults with type 2 diabetes (de Jager and colleagues, Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency, BMJ, 2010), metformin lowered serum B12 by a mean of 19 percent over 4.3 years

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Clinical Chemistry 50 (1): 332

However, research performed by doctors explains that when people can properly absorb and store vitamin B12, it is stored within the body for between 3 to 5 years

[41] : 976 Gastric bypass surgery [edit] Various methods of gastric bypass or gastric restriction surgery are used to treat morbid obesity