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The fixed 2mg dose was effective across body weight ranges in clinical trials

For instance, CR combined with radiotherapy, has been shown to modulate the TME in a triple-negative breast cancer model by decreasing the number of intratumoral Tregs, increasing the CD8 + cell: Treg ratio, and upregulating PD-1 expression on CD8 + T cells

A defining molecular hallmark is global DNA hypomethylation in lymphocytes, especially CD4+ T cells, which associates with disease activity and stabilizes a type-I-interferon-driven program

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