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10.1039/C8FO02004C 185 ZhangW.MiikedaA.ZuckermanJ.JiaX.CharugundlaS.ZhouZ.et al (2021)

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3.1.2 Clinical manifestations of mutual influence The comorbidity of chronic constipation and depression leads to complex clinical presentations, with the two conditions mutually influencing each other to form a vicious cycle that significantly impairs quality of life

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