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Naringenin demonstrates dose-dependent urate-lowering and anti-inflammatory renal effects by inhibiting XOR and modulating inflammatory pathways (Yang Y

Brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) levels in post-mortem brain tissue from patients with depression compared to healthy individuals - a proof of concept study

This dual regulation fosters cytoskeletal remodelling, extracellular matrix degradation, and metastatic dissemination, thereby driving malignant tumour progression

This animal work was approved by the Institutional Animal Care and Use Committee of the National Institute of Environmental Health Sciences

Interestingly, the observations extracted from computational analysis were in accordance with the calculated in vitro enzyme inhibition activities, i.e., stronger interaction of C3G (glycosylation of 3-OH group) via A-ring with binuclear copper ion results in its complete oxidation by the enzyme against EC and CH compounds