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Closure and Interpretation The clinician interprets clinicalresponse patterns, laboratorytrend data, and adverseevent profiles to determine whether isotretinoin is providing sustained acnecontrol without unacceptable toxicity, then adjusts dose, duration, or adjunctive therapies as needed

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2 Gastroenterology (2012) Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failureThe pivotal STEPS trial (PMID 22982184)

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We also show that the enzymatic oxidation of Tyr proceeds faster in the presence of Cu(II) ions