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Antidepressants, Drug Interactions, and Safety Notes Tirzepatide has no significant documented pharmacokinetic interactions with common antidepressants, but absorption changes from vomiting or diarrhea, and behavioral changes from rapid weight change, can affect psychiatric meds

Reprod Biol Endocrinol 20 , 72 (2022)

Slemmer JE, Shacka JJ, Sweeney MI, Weber JT

In the Phase 2 trial, participants who skipped lower doses and jumped directly to higher ones experienced nearly double the rate of GI side effects compared to those who followed the full titration schedule

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With their article, the three authors therefore want to bring clarity to the current discussion