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4a, NAC treatment markedly increased NADPH (+281 57 %, p = 0.035),while it diminished Kyn (55 16 %, p = 0.04), HCA (66 7 %, p = 0.0008), N-acetyl-glutamine (37 7 %, p = 0.015), succinic acid (34 6 %, p = 0.025), cytidine (50 9 %, p = 0.027), hypoxanthine (45 10 %, p = 0.032), cAMP (58 6 %, p = 0.033), methyl-malonic acid (33 7 %, p = 0.035), acetyl-coenzyme A (27 4 %, p = 0.044), flavone (46 11 %, p = 0.045), and CDP-choline (28 7 %, p = 0.048)