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The combination is used to prevent and manage deficiencies of these vitamins, to support pregnancy needs (folic acid), and to address peripheral neuropathy and macrocytic anaemia related to B12 and folate insufficiency

Critical roles in angiogenesis (VEGF) and cellular signaling pathways

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The zonulin-induced disruption of the tight junction complex allows paracellular transport of gliadin and the eventual uptake of gliadin into systemic circulation, thereby causing the inflammatory response exhibited by patients with celiac disease (26, 34, 35)

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