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Peptide transformations are moderate and permanent

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Collectively, these results suggest the presence of a common mechanism for overlapping functional redundancy in IGF and insulin signaling pathways and may explain our observation of persistent increased proliferation in growth plate chondrocytes from mice lacking IR

10.1242/jcs.093849 58 KaganV.JiangJ.HuangZ.TyurinaY.DesbourdesC.Cottet-RousselleC.et al (2016)

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You inject someone with DMT, blood levels rise, they reach the brain and then almost immediately they start collapsing down again exponentially