Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss
Oral supplements are available, but most veterinarians prefer the injections, the thought being that they are more reliable since were dealing with cats who have demonstrated a compromised ability to absorb cobalamin through their GI tracts
And when used alongside synergistic therapies like GLP-1 peptides or NAD+ protocols, it forms a powerful foundation for total-body rejuvenation
You have to consume food and drinks that have vitamin B12 to get it
It is commonly explored for its relationship to NNMT activity, with research interest centered on how that pathway may influence fat metabolism, lean mass support, and energy balance
Vitamin B12 injections versus oral supplements