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59 In that trial, 731 patients with HFpEF and BMI 30 kg/m 2 were randomised to receive tirzepatide or placebo for at least 52 weeks

Goto, H

doi: 10.1038/nrn.2018.8 58 HanWTellezLAPerkinsMHPerezIOQuTFerreiraJet al

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Carla Gaggiano and Riccardo Terribili critically revised the manuscript

Effective alternatives during the adjustment period: Leg press instead of heavy free-weight squats Machine press instead of barbell bench press (easier to bail safely) Seated rows instead of bent-over rows (less abdominal compression) In general, machine-based exercises work well in times of low energy