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NAD+ (nicotinamide adenine dinucleotide) is a critical coenzyme involved in cellular energy metabolism, DNA repair, and mitochondrial function [1]

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Factors Contributing to Vitamin B12 Deficiency Several factors can contribute to Vitamin B12 deficiency, including reduced stomach acid production in the elderly, which hinders B12 absorption from animal proteins

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doi: 10.1038/nature13198

NNMT is expressed most highly in human liver (RPKM 188.3), followed by the appendix (RPKM 69.3) and approximately ten other tissues, with a biased expression pattern