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The top dose produced 20.9% average weight loss over 72 weeks and 20.2% in a direct comparison with semaglutides 13.7%. Its second receptor, GIP, separates tirzepatide from approved single-receptor GLP-1 drugs and helps explain the larger population-level weight loss. That 20.9% came from participants averaging about 105 kg at a BMI of 38, most of whom were sedentary

The heart-rate cost is mostly the glucagon arm: GLP-1 on its own nudges heart rate up a little and then flattens, while glucagon carries the part that keeps climbing with the dose

Avoid laying down after eating

Eggs: 2 large eggs provide 43% of the DV (22,28)

This prevents the bones from moving and allows blood vessels and new bone-forming cells to cross the fusion site