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This axis becomes particularly pronounced in PCOS, where hyperandrogenism-driven adipocyte hypertrophy and insulin resistance create a cytokine-saturated, lipotoxic microenvironment that continuously recruits and activates neutrophils [31]

doi: 10.1097/MD.0000000000035394 68 RajagopalSAlruwailiFMavratsasVSernaMKMurthyVLRajiM

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6, acute irradiation caused a pronounced suppression of the mitophagy machinery, reflected by significant decreases in renal (A) PINK1, (B) Parkin, and (C) ATG5 protein levels by 83.7%, 75.3%, and 87%, respectively, compared with the normal group