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Selective serotonin reuptake inhibitor (SSRIs) can bind to the COMT catalytic site, as a COMT inhibitor, and inhibit SAMe access, thus preventing the methylation of COMT substrates [185]

Namely, carbamoyl phosphate synthetase 2 (CPS 2) can accept the amide group from glutamine to generate carbamoyl phosphate, a rate-limiting step in pyrimidine synthesis

(2018) confirmed that MenSCs increase the expression of brain-derived neurotrophic factor, thereby supporting neuronal survival and axonal regeneration (Uchida et al., 2016)

doi: 10.1002/14651858.CD002286.pub2

doi: 10.1073/pnas.0903229106 195 MallaviaL

Food supplements should not be considered a substitute for a varied, balanced diet and a healthy lifestyle