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The importance of cytokines for DPP4 activity was demonstrated in chronic B lymphocytic leukemia cells, where interferons , , and stimulated STAT1 to bind the GAS (interferon -activated sequence) consensus sequences in the promoter of the DPP4 gene, leading to up-regulation of both intracellular and cell-surface DPP4 expression as well as DPP4 activity (46)

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They stimulate insulin secretion and inhibit the release of glucagon by the beta and alpha cells of the Langerhans islets of the pancreas, thereby reducing postprandial plasma glucose levels.68 They also reduce gastric emptying time and body weight