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Regulatory feedback mechanisms leading to an increase in the dietary absorption of LC, and/or de novo synthesis may take place to overcome the LC deficiency and reduce the loss by urinary excretion

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This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 27,99 / 30 days cancel any time Subscribe to this journal Receive 12 digital issues and online access to articles 135,68 per year only 11,31 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout References NCD Risk Factor Collaboration

RyR1 residue Val4820 is replaced by a Phe in RyR2, which would cause a large clash with Ator1 and AtorC in the open and closed-state structures