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sativa extract has been accepted and recognized as safe by the Food and Drug Association in the United States (90)

The FDA has already signaled openness to reducing mandatory animal testing requirements where validated alternatives exist, accelerating the transition from preclinical to first-in-human studies

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For more complex matrices, liquid chromatography-mass spectrometry techniques have been developed to detect and measure curcumin traces in food, biological fluids, and other samples (189)

Since LC is still used by the athletes [9, 10], the aim of this systematic review is to evaluate the effect of prolonged LC supplementation on metabolism/metabolic changes in healthy human subjects

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