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Weeks 1 to 2: Sleep depth

Unlike Mounjaro which activates two receptors (GLP-1 and GIP), retatrutide activates three - GLP-1, GIP and glucagon -producing the strongest weight loss results seen in any pharmacological trial to date

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To address this, we developed a chimeric GLP-1A that targets transporter-mediated endocytosis to enhance cellular permeability to GLP-1A by utilizing the transporters available in the intestine, particularly the apical sodium-dependent bile acid transporter (ASBT)

Morton D, Eilber FR, Malmgren RA, Wood WC