Antagonists of cannabinoid receptors inhibited the analgesic activity of acetaminophen by reducing the responsiveness of mice to nociceptive stimuli, attributable to the modulation of cytokine and NO pathways [22,23]
Specifically, this included increased ( Egr, Nos, Srf, and Kras ) or decreased ( Egr, Vegfr, and Plc ) gene expression, while Akt1 gene expression remained unchanged (Vukojevic et al., 2018)
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Psychiatry 57 , 126133 (2005)
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avoid repeated freezethaw