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The PINK1/Parkin pathway governs mitophagy: mitochondrial membrane potential (m) collapse stabilizes PINK1 on the outer membrane, phosphorylating ubiquitin to recruit Parkin, which ubiquitinates mitochondrial proteins (e.g., Voltage-Dependent Anion Channel 1 (VDAC1)) for autophagic degradation [159]

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These essential fats comprise a substantial portion of brain tissue structure

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