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Elegant studies of this type have been done for example by Leshan and colleagues to show that only a subpopulation of VTA dopamine neurons projecting specifically to the amygdala but not the NAc is activated by leptin (Leshan et al., 2010)

doi: 10.2174/138920371604150429154840 97 ErdamarHCimenBGlcemalHSaraymenRYererBDemirciH

This is much easier to measure than a solution with a strange concentration

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Oral Oncol (2002) 38(7):71422