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(Figure 1) In gut L-cells, the Cterminal portion of proglucagon is predominantly processed to glucagon-like peptide-1 (GLP-1) and GLP-2

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Metabolic reprogramming has also been shown in macrophage activation, where pro-inflammatory macrophages increase aerobic glycolysis and decrease mitochondrial respiration as soon as four hours post exposure to a bacterial-derived lipopolysaccharide [72]