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Descriptor-based screening A descriptor-based analysis was conducted to compare global physicochemical profiles between all reference agonists and candidate molecules from DB, FDB, and Molport libraries

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Participants who had high urinary excretion of toxic metals were selected to continue on to phase 2

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thaliana mutant lines used in our study were ordered from the European Arabidopsis Stock Centre (NASC) or kindly donated by authors (see Supplementary Table S1 for further details)