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The medication must be administered into the fatty layer beneath the skin, not into muscle or directly onto the skin surface

However, the application of estrogen also presents several side effects, such as stimulation of the gastrointestinal tract, an increased risk of thrombosis, and the potential risks of breast cancer, endometrial cancer, and venous thrombosis (Zhao et al., 2025)

Retatrutide is an investigational medication being studied as a triple hormone receptor agonist targeting GIP, GLP-1, and glucagon receptors

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