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In April 2025, a research article demonstrated how GLP-1s might drive depression and suicidal ideation in people with a genetic predisposition toward low dopamine function

Key takeaways No, it is not recommended to skip a week of Wegovy, even while on vacation

Providers serving dual-eligible populations should prepare for increased utilization and questions around eligibility and documentation of comorbidities

With regards to neurodegenerative diseases such as AD and PD, the literature has demonstrated the inhibitory effects of GLP-1 on pro-inflammatory cytokines such as TNF-alpha and IL-1betatwo notorious small molecules identified in the microglial-mediated injury observed in said diseases processes

Conclusion and future perspectives It is unequivocal that the risk and burden of HFpEF is increasing due to aging of population, the global epidemic of obesity and T2DM

A real primary care practice can follow the whole patient