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If you have been on a stable therapeutic dose (0.5 mg, 1 mg or 2 mg weekly) for several weeks and experience no reduction in appetite, your healthcare provider may need to reassess your treatment plan

The pharmacokinetic argument is solid (the math is well-understood for any GLP-1 with a long half-life), but efficacy and safety in a split protocol haven't been formally tested

It depends on factors like how much weight is lost, individual body composition, and whether the person is maintaining muscle mass through exercise

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Many patients experience serious side effects, including gallbladder complications